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Co-Authors
- N. I. Kochar
- M. N. Dahake
- R. L. Bakal
- A. P. Devani
- R. S. Sakhare
- A. B. Roge
- A. D. Dewani
- M. D. Kshirsagar
- Rakhee K. Kotecha
- Anand S. Surana
- P. D. Nakhat
- N. P. Jogad
- M. B. Mundlik
- C. K. Gadewar
- N. A. Chandekar
- N. M. Mahajan
- P. D. Telgote
- R. A. Hajare
- R. M. Gaurkhede
- P. P. Chinchole
- A. S. Wandhare
- S. S. Karki
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Chandewar, A. V.
- Method Development and Validation of Ramipril and Amlodipine Besylate by RP-HPLC
Abstract Views :206 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, P.W. College of Pharmacy, Dhamangaon Road, Yavatmal, 445001, IN
1 Department of Quality Assurance, P.W. College of Pharmacy, Dhamangaon Road, Yavatmal, 445001, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1829-1832Abstract
A simple isocratic RP-HPLC method has been developed and subsequently validated for the determination of Ramipril and Amlodipine Besylate in pharmaceutical dosage forms within very short retention time. The method employs an Xterra C18 column, 5 μ, 150 mm x 4.60 mm id with flow rate of 1.5 ml/min using UV detection at 210nm. The separation was carried out using a mobile phase consisting of Sodium Lauryl Sulfate buffer by adjusting pH 2.5 and final composition is Buffer: Acetonitrile: Methanol (45:16.5:38.5)V/V. The retention time for Ramipril and Amlodipine Besylate was found to be 3.1 minutes and 3.8 minutes respectively. The results of analysis were validated statically and by recovery studies. Hence the proposed method was found to be accurate, precise, reproducible and specific and can be used for simultaneous analysis of these drugs in tablet formulation.Keywords
RP-HPLC, Sodium Lauryl Sulfate Buffer, Ramipril, Amlodipine Besylate.- Simultaneous RP-HPLC Determination of Drotaverine Hydrochloride and Mefenamic Acid in their Combined Tablet Dosage Form
Abstract Views :170 |
PDF Views:1
Authors
Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal-445001 (M.S.), IN
1 P. Wadhwani College of Pharmacy, Yavatmal-445001 (M.S.), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 986-989Abstract
A simple, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatographic procedure was developed for simultaneous determination of Drotaverine HCL and Mefenamic Acid in tablet dosage form at a single wavelength. The mobile phase used was a combination of Methanol:Acetonitrile:KH2PO4 Buffer (10 mM):(40:40:20) pH 3.5. The detection of the combined dosage form was carried out at 240 nm and flow rate was set to 1ml/min. Linearity was obtained in the concentration range of 3 to 30 μg/ml of Drotaverine HCL and 6 to 33 μg/ml of Mefenamic Acid with correlation coefficients of 0.9998 and 0.9999, respectively. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.Keywords
Drotaverine HCL, Mefenamic Acid, RP-HPLC, Simultaneous Estimation.- Analytical Method Development for Phenylpropanolamine Hydrochloride Sustained Release Pellets
Abstract Views :176 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, P.W. College of Pharmacy, Yavatmal, Maharashtra, IN
2 Department of Pharmacology, S.K.B College of Pharmacy, Kamptee, Maharashtra, IN
3 Pharma Research, Wochardt Research Centre, Aurangabad, IN
4 Formulation and Development, Inventia Health Care Pvt. Ltd., Thane, IN
1 Department of Pharmaceutics, P.W. College of Pharmacy, Yavatmal, Maharashtra, IN
2 Department of Pharmacology, S.K.B College of Pharmacy, Kamptee, Maharashtra, IN
3 Pharma Research, Wochardt Research Centre, Aurangabad, IN
4 Formulation and Development, Inventia Health Care Pvt. Ltd., Thane, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 398-400Abstract
The main aim of the present study was to developed analytical method for phenylpropanolamine hydrochloride (PPH) in PPH sustained release pellets. Analysis of PPH i.e. assays and dissolution has been given in USP by HPLC method. No UV-Visible spectrometry method has been reported for the analysis of PPH. Analysis of PPH was carried out by using UV-Visible spectrometry after performing the part method validation of specificity (scanning the standard solution of PPH), filter paper validation and linearity. Sustained release pellets were fabricated containing PPH by solution/suspension layering technique. A solution of PPH was prepared in distilled water and UV spectrum was taken using Perkin Elmer, Lambda25-UV/Vis Spectrophotometer. Filter paper validation was done by filtering standard PPH solution (10 ppm) through Whatman filter paper No. 41 and absorbances of filtered solution was taken repetitively and compared with unfiltered solution at 205 nm. There was negligible changed in absorbance was obtained. The data for calibration plot showed good linear graph with r2=0.9980 for PPH. According to international conference on harmonization (ICH) guidelines, the present method was validated for precision, repeatability and recovery.Keywords
UV-Visible Spectrophotometer, Phenylpropanolamine Hydrochloride, Sustained Release Pellets.- RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium Ezetimibe in Pharmaceutical Formulation
Abstract Views :152 |
PDF Views:0
Authors
M. B. Mundlik
1,
C. K. Gadewar
1,
N. A. Chandekar
1,
N. M. Mahajan
1,
P. D. Telgote
1,
A. V. Chandewar
1
Affiliations
1 Dept. of Pharmaceutical Chemistry, P. Wadhwani College of Pharmacy, Dhamangaon Road, Yavatmal-445001, IN
1 Dept. of Pharmaceutical Chemistry, P. Wadhwani College of Pharmacy, Dhamangaon Road, Yavatmal-445001, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 485-490Abstract
A simple, selective, rapid and precise reverse phase HPLC method has been developed for the simultaneous estimation of Atorvastatin calcium and Ezetimibe in pharmaceutical dosage form. A Hypersil BDS (250 mm×4.6 mm i.d 5μ) column was used for Separation. The mobile phase was Acetonitrile:water:Methanol (350:550:100, v/v) and adjust Ph to 4.0 with Orthophosphoric acid. Flow rate 2.0 ml/min with detection at 250 nm. The retention time of Atorvastatin calcium and Ezetimibe was 21.712 and 10.414 min. respectively. The developed method was validated in terms of accuracy, precision, Linearity, specificity and forced degradation, robustness, solution stability, system suitability, limit of detection. The proposed method can be used for these drugs in combined dosage forms. The proposed RP-HPLC Method for the simultaneous estimation of Atorvastatin calcium and Ezetimibe in combined dosage form is accurate, precise, linear, rugged, robust, simple, rapid and selective. It can be easily adopted for routine quality control (QC) analysis of raw materials, formulation studies. pH of the mobile phase is 4, which is good to increase the shelf life of the column.Keywords
RP-HPLC, Atorvastatin Calcium, Ezetimibe.- Synthesis, Structure and Spectral Charectarization of Friedal Craft N-Benzylation of Isatin and Their Novel Schiff’s Bases
Abstract Views :157 |
PDF Views:0
Authors
R. A. Hajare
1,
R. M. Gaurkhede
1,
P. P. Chinchole
1,
A. V. Chandewar
1,
A. S. Wandhare
1,
S. S. Karki
2
Affiliations
1 P.W. College of Pharmacy, Dhamangaon Road, Yavatmal-445001 (M.S.), IN
2 K.L.E. College of Pharmacy, Rajaji Nagar, Bangalore-560010, IN
1 P.W. College of Pharmacy, Dhamangaon Road, Yavatmal-445001 (M.S.), IN
2 K.L.E. College of Pharmacy, Rajaji Nagar, Bangalore-560010, IN